A New aDENNDum to Genetics of Childhood Asthma
نویسندگان
چکیده
Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a molecular basis for how DENND1B contributes to asthma pathogenesis.
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ورودعنوان ژورنال:
- Cell
دوره 164 شماره
صفحات -
تاریخ انتشار 2016